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The prefix 'crani-' specifically refers to the skull in medical terminology. It derives from the Greek word "kranion," which means "skull." This prefix is commonly used in various medical terms that relate to the skull, indicating structures that are associated with it or conditions that affect it. For instance, the term "cranial" refers to anything related to the skull, such as the cranial cavity, which houses the brain. Understanding this prefix allows for a better comprehension of anatomical and medical language, especially when it comes to discussing conditions, procedures, or structures that involve the skull.